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What is Modafinil?
Modafinil, brand name Provigil, is a wakefulness-promoting drug used for the treatment of disorders such as narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. It is thought to work by altering the natural chemicals (neurotransmitters) in the brain. Provigil is used to treat excessive sleepiness caused by sleep apnea, narcolepsy, or shift work sleep disorder.
Do you want to Buy Modafinil in the VN in 2020?
Do you live in the VN and are wanting to buy the narcolepsy medication called modafinil? Be aware that in the VN that buying Modafinil requires a prescription. If you need a prescription, our online doctor's service can help you obtain one if you meet the requirements.
Modafinil is a medicine which is used to treat a sleeping disorders called narcolepsy. This condition causes people to spontaneously fall asleep. It is also used to treat other sleeping disorders such as those experienced by shift workers or those suffering from sleep apnea. It can also be prescribed to treat ADHD.
While there are uses of modafinil which are purported to help people stay alert and awake, this drug may not be marketed as a "nootropic" in the VN. It may only be used as prescribed as a treatment for narcolepsy or other conditions listed above.
There are many different brands for the modafinil drug. Some of these names, as marketed in the VN, are Modalert, Modvigil, Provigil and Modafinil MD. Regardless of the brand, they all consist of modafinil drug, which is used for narcolepsy.
What is armodafinil? It is another common form of modafinil. The compound is similar in nature to modafiil and goes by various brands, including Waklert, Artvigil and Nuvigil. Both drugs treat narcolepsy. Your doctor can help you understand the difference between these two drugs.
How Does Modafinil Work?
It works by stimulating areas of the brain that regulate the patterns of being awake and sleeping. They target the "awake" side by stimulting neurotransmitters.
It is a narcolepsy medication that promotes wakefulness. While some people call them "smart drugs" or "nootropics", we only say they are a narcolepsy medicine. The branded name is Modalert, and the generic is Modafinil.
Modalert, also called Provigil, works by blocking dopamine transporters. These molecules remove dopamine from brain synapses. This increases the amount of dopamine in the brain, which is the brain's "reward" mechanism. It is used to treat work sleep disorders and shift work sleep disorder. Order them today from Pro Modafinil.
You can buy Provigil, Modalert and Modafinil in the VN. It is for sale at pharmacists or in our online store. You can get next day delivery of Modafinil VN most days of the week from Pro Modafinil. Order Provigil online by clicking the order button located above. We have cheap modafinil, and you can get the best price at Pro Modafinil.
How to take Modafinil
Modafinil pills should be taken once a day orally. It can be taken with or without food. It is recommended to check with your doctor if there are any time preference when you better take it. Usually, It is taken in the morning.
If you use Modafinil for the treatment of shift work disorder, then you better take it an hour before you start your shift. Better to take it at the same time, if possible, and only change that after consulting your doctor.
Modafinil will only help to reduce sleepiness, but it will not treat your condition. Therefore you need to continue taking Modafinil even if you feel rested.
Mode of Action
Its mode of action used to be a mystery, but modern findings suggest that it acts as a very weak and selective atypical dopamine reuptake inhibitor as it behaves similarly to other drugs in this classification. There is a lot of evidence to support the claim; however, it is also thought that there are a lot more mechanisms at work.
As mentioned, Modafinil is linked with narcolepsy which makes it a good treatment option for narcolepsy and other sleep-related problems and disorders. Since there is a huge risk for developing hypersensitivity reactions and neuropsychiatric disorders when taking the drug, the European Medicines Agency recommends in limiting the prescription of the drug to patients who suffer from narcolepsy only.
Contraindications to Modafinil Use
Similar to other medications and drugs, the first and foremost contraindication to its use is allergy and hypersensitivity. In the case of Modafinil, it is the only contraindication for its use. However, Cephalon has distributed literature advising that it is still important to consult a physician before taking the drug as people may experience problems related to hypersensitivity to constituents of the tablet. People who suffer from cirrhosis can also have problems with the drug as their condition may impair the metabolism of Modafinil. Of course, people with cardiovascular problems are always susceptible to problems brought on by certain drug interactions especially those that affect the nervous system and neurotransmitters.
Just like any drug and medication, Modafinil affects people differently and may show adverse reactions that aren't beneficial to the person. As with any drug, the effects may or may not appear on a particular person which is why it requires proper clinical studies and trials. Teva Pharmaceuticals provides documentation about the adverse effects of the drug. According to their clinical trials, 1/3 of their participants have experienced headaches when taking the drug while 11% suffered from nausea. Other side-effects that participants experienced include: diarrhoea, nervousness, insomnia, dizziness, and GI problems although these problems were only experienced by less than 10% of the participants.
There are also the sporadic cases of severe adverse effects such as severe skin rashes or other allergy-related symptoms. From December 1988 which was the date of the drug's initial marketing up to the end of January 2007, the US FDA has received only six cases of severe cutaneous adverse reactions. These include the following skin reactions: SJS, Erythema Multiforme (EM), TEN, and DRESS. These affected both adults and paediatric patients. Because of this, the FDA needed to issue an alert regarding the medication, and they also noted that multi-organ hypersensitivity and angioedema had been reported in postmarketing. This prompted the FDA to order Cephalon to change their Provigil leaflet with a bold-face print of some serious and potentially fatal adverse effects such as TEN (toxic epidermal necrolysis), SJS (Stevents-Johnson Syndrome), and DRESS.
When it comes to long-term effectiveness and safety, its effects haven't been determined. It is thought that Modafinil may have adverse interactions with hormonal contraception which can last for more than a month after the last dose. But all medications can be un-safe make sure you consult a doctor before taking any medication.
Potential for Dependence and Addiction
When it comes to the potential for being an addictive substance, the chances for Modafinil are incredibly low. It does, however, share some biochemical mechanisms with other stimulant drugs that are addictive. According to some studies, the drug shows very similar mood-elevating properties but significantly less. Monkeys will mostly self-administer if they have been trained to self-administer cocaine. The drug doesn't display a reinforcing effect when tested on mice that are given the therapeutic human dose although it does show a little effect when given higher dosages. Although it is scarce, some cases show Modafinil abuse does exist. This is partly the reason why the drug is considered as a schedule IV controlled substance in the US. This category is reserved for medication that has a valid medical reason to be used and has a low but still significant addictive potential.
Very little psychological dependence has been recorded with the drug and the only known cases have been reported in conjunction with daily overdose for extended periods. There are, however, reported withdrawal symptoms like lethargy, anhedonia, insomnia, and anxiety.
There have been extensive clinical studies done about the subject and, so far there is no evidence that shows that people using Modafinil tablets will develop tolerance when taking the drug at therapeutic doses even when used for a long period lasting for 40 weeks to three years.
Overdosing on Modafinil
When tested on rats, the median lethal dose was approximated to a little bit above 1250 mg/kg. The median dose reported for oral dosages on rats was reported to be 1000-3400 mg/kg. IV median dosage for dogs, on the other hand, was at 300 mg/kg. Clinical trials done for humans were done at 1200 mg./day ranging from 1 week to three weeks. There is a reported one-time case of overdose up to 4500 mg but it didn't cause any life-threatening effect. It did result in a lot of adverse reactions such as insomnia, agitation, aggressiveness, irritability, nervousness, confusion, palpitations, tremors, nausea, sleep disruptions and diarrhoea. The FDA maintains its stand that there is no fatal overdose associated with Modafinil use although it is for only drugs as multiple ingredient drugs.
Drug to Drug and Other Interactions
Taking Modafinil tablets with other opioids like hydrocodone, fentanyl, and oxycodone can result in a drop in a plasma concentration in the body. This is because Modafinil is largely dependent on the CYP3A4 enzyme. If not monitored, this can cause reduced effectiveness and withdrawal symptoms.
The drug's effectiveness is largely dependent on the status of catechol-O-methyl transferase or COMT in the body. This is the one responsible for the improvement in vigour and energy during sleep deprived moments. Some studies are suggesting that people with Val/Val genotype will experience an even greater cognitive improvement in taking the drug while those who have Met/Met genotyping will experience little improvement.
History of the Drug
The drug was primarily developed in France by the emeritus experimental medicine professor and neurophysiologist Michel Jouvet at Lafon Laboratories. The drug was first developed in the late 1970s during the invention of a series of benzhydryl sulfinyl compounds. This includes adrafinil and was offered as an experimental treatment option for narcolepsy back in 1986. Modafinil came into being since it was the primary metabolite of the drug mentioned above. It lacked the â€“OH group on the last amide which gives it a similar effect to the parent drug but has greater use. It has been used in France since 1994 under the brand name Modiodal.
On the other hand, it has been in use in the US since 1998 under the brand name Provigil. The US FDA approved the drug for narcolepsy treatment during this year and later added in 2003 to treat obstructive sleep apnea and shift work-related sleep disorder. This was added even though studies have shown that amphetamines and caffeine have proven to be more effective in promoting narcolepsy based on the Stanford Sleepiness Test Score. It is marketed by Cephalon Inc in the country as they originally leased the rights from Lafon before buying the company back in 2001.
Cepahlon started marketing the R-enantiomer arModafinil form of Modafinil in the US in 2007. Generic versions of the drug became available in 2012 due to protracted patent litigation.
How to Purchase Modafinil in the VN
In the Viet Nam, the drug was first approved in December 2002.
Is it legal to take Modafinil? It has been legal purchase in the VN from online pharmacies since 2002. We sell 200 mg pills here at Pro Modafinil. For our price, check above. When it comes to sports, the use of the drug is somewhat controversial as high-profile cases attract a lot of press coverage. There are a lot of prominent athletes in the US that have tested positive for the drug. They protested that it doesn't belong to the prohibited list at the time. However, the WADA or World Anti-Doping Agency maintains that even if the drug itself isn't in the banned list, it is still related to already banned substances. This prompted them to add the drug to the list of prohibited substances on August 3, 2004 ten days before the start of the 2004 Summer Olympics.
Please do not use this drug as a nootropic. Modafinil is not to be sold in the VN under the term "nootropics", only as a treatment for narcolepsy.
For Depression: After 3 months I quit taking Zoloft for depression after taking Modafinil. It gives me energy from chronic fatigue also. I'm a teacher and I also notice I'm much more alert and focused while taking it. I have mild bipolar 1 also and take Seroquel and Lamictal also. I can't detect any side effects unless I have to take it with my asthma inhaler as then it can cause shakiness, nervousness, sleeplessness, etc. Otherwise it's a great product! I found Zoloft to "numb" me to a degree--I didn't feel sad but I didn't feel happy either. Kind of desensitized
Provigil (modafinil) for Narcolepsy: This med has been very helpful for my excessive daytime sleepiness (Idiopathic Hypersomnia). Probably saved me from ending my career as a therapist altogether, although I’m limited to seeing half the usual number of clients. First 100 mg dose at 8 am and I’m good to go for about 4 hours—and quite talkative and energetic. By noon or 1 I’m getting quite tired and, even though I take my afternoon dose of 100 mg, the rest of the day I typically feel quite tense and often irritable. Tight knot in upper back. Seeing clients is a real challenge. My life remains pretty limited by my idiopathic hypersomnia but I’m so relieved to at least be able to work enough to support my family. Losing that capacity altogether would have been devastating, so I’m very grateful for Provigil.
For Chronic Fatigue Syndrome: Please be very very careful taking this. My life is now in turmoil because of my addiction to this medication. As I write I’m searching the internet to find a supplier. I’m terrified of running out in 3 days. There is an underground consensus on the physical and psychological withdrawals. The best I can do is share my experience with others to hopefully avoid terrible heartache in your life, I’ve already messed mine up. Please try and get by without this medication it does work and works very very good, hence my addiction. But again I want to help people before they get into the situation I’m in. I know many others as well that struggle with this. Please be careful if you decide to take this.
For Narcolepsy: I have been taking 400 to 600mg of modifinil, each day for 20 years, due to narcolepsy, and excessive daytime sleepiness. The Only side effect I have ever noticed, was a decrease in falling asleep during the day. Which is exactly what I need. It took nearly 20 years to get diagnosed with this sleep deprivation. I had many encounters with the law, and driving both before and after being diagnosed. However far less, after. I still have to have Ritalin, or some amphetamine, in the event, the current dose of 400mg a day wears off. Ritalin helps me on a shorter duration, such as in the evening, when an hour or two of wakefulness is needed, rather than the 12 hours typically provided to me by provigil/modifinil. Modifinil is a life saver for me. I was a danger to myself and others, without it. However, $5, 249 for 180 pills, a 90 day supply, is ridiculous.My fixed S. S. I is less than$3000 for 90 days.Thank God for Hip insurance in Indiana.
For Depression: I take modafinil on and off for OCD & Depression and it works. I have high blood pressure that is treated with meds and this doesn't seem to bother it too much. It messes with my anxiety but not enough to stop using it. If you want to get a job done then this is for you.
Provigil (modafinil) for Narcolepsy: I have narcolepsy with cataplexy. Adderall, Ritalin, etc. did nothing for me. I’ve only been taking this for a short amount of time but unlike adderall or ritalin this not only physically keeps me awake but I don’t feel the horrible fatigue I usually do. It keeps me awake and feeling good while also easing any nervousness I have. I feel very calm while also being energized.:)
For Fatigue: I've been using Modafinil for a while now, mostly in periods where I have a lot of work to do and can't afford enough sleep, having a young son additionally. I've experienced noticeable less fatigue and better concentration, but also somehow it seems to making social interactions less stressful (I must say I'm not having any kind of social anxiety, just being maybe a shy person). Absolutely no side effects noticed, it starts working after 2 to 3 hours and lasting for about 8 to 12 for 200mg dose.
For Shift Work Sleep Disorder: Modafinil saved my life! I have had hypersomnolence my entire life. I could easily sleep 4 days straight and wake up confused, dehydration, and guilty for missing my children's school performances, graduations, holidays, vacations etc. @ almost 37 y/o I was finally diagnosed and prescribed modafinil. From day one I woke up @ 5am. I cleaned my house, got my hair and nails done, took my kids to and from school, scheduled appts that I should've schedule months ago, cooked dinner, and had a wonderful outlook. I went to sleep around 10pm. The next day I woke up @ 5am.and stay awake, happy and productive all day! This has continued from day one!!!!! This med is magic for me. I'm so grateful. My only wish is that I had been dx'd 30 years ago!
For Depression: Modafinil helps me feel human. I have had major depression since I was 15 years old. Finally something worked. I developed severe apnea and was prescribed modafinil. Totally unintended but my depression started to subside. Unfortunately, it doesn't stay away if I stop taking modafinil. I asked my psychiatrist to prescribe it for me. He would not. My debate was this, I had taken every single drug cocktail thrown at me for years and years. I never blinked. I complied. Now I find something that works and I can't have it? Put me in a study. I'll do whatever it takes, I said. I'm telling you I have my life back. I can feel happy and hopeful again. He said No.
For Fatigue: The first time I took modafinil was amazing. I’m having a hard time so using it for productivity at the desk, however it lifts my mood right away and it also makes me enjoy stuff more and be more social. I have insomnia so either way I have to take sleep pills this makes my sleep aid need stronger so undecided. I think the trick for office work is to only take once you took the first step in the project at hand otherwise it will help procrastinate because it gives energy for other things and makes u stay focus in that thing till u finish. I have hope for this medication but I have to figure out my dosage , frequency etc For the headaches just drink plenty of water before you get the headache and you won’t. Good luck ! I don’t have narcolepsy but rather insomnia.
For Narcolepsy: I have severe narcolepsy without cataplexy and have been taking Provigil/Modafinil for about 12 years now. I started on 200mg but found it didn’t do much to help. After a couple months at 200mg I was then prescribed 400mg and have remained at that dose ever since. This medicine has truly changed my life. I take the full dose about an hour after waking up and eating something (seems to be more effective after eating). Insurance made me try Nuvigil right after it hit the market and the Nuvigil put me into a deep sleepiness state for more than 36 hrs, will never take that again!!! Seems that some of the manufactures versions aren’t as effective as others, as I’ve just been switched to Alembic’s Modafinil and it’s not giving me that fully awake feeling that Provigil, & Heritage versions do.
For Depression: For me it's impressive! After my Burnout and the following depression, it was a struggle for me, that I wasn't able to bring the past performance. Lack of energy and concentration, mood swings, bad memory, and so on. With Modafinil I am able to work focused on my dream, fight procrastination (which was a real problem), think-power from past days (I often gave up when I had so solve something complex) I don't take it every day, sometimes only 1-2 days a week. Mostly when I'm working on my project or when I feel really bad. Side Effects: Headache during effect-phase (when I started, but was gone after the third intake) Insomnia (when you take it too late)
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